• Poster presentation to feature data from VBI’s Phase IV clinical study of Sci-B-Vac®, which demonstrated rapid seroprotection and high levels of hepatitis B antibodies after two vaccinations
  • Sci-B-Vac® is a third-generation Hepatitis B vaccine that contains the S antigen, pre-S1, and pre-S2 surface antigens of the Hepatitis B virus

VBI Vaccines Inc. (Nasdaq: VBIV) (TSX: VBV) (VBI) today announced the company’s abstract, “Antibody and Cell-mediated Immunity against PreS1, PreS2, and S Antigens after Immunizations with a Third Generation Hepatitis B Vaccine,” has been selected as a Presidential Poster of Distinction for presentation at the 68th annual meeting of the American Association for the Study of Liver Diseases (AASLD), The Liver Meeting® 2017, in Washington D.C. on October 23, 2017.

Dr. Francisco Diaz-Mitoma, M.D., Ph.D., VBI’s Chief Medical Officer, will present the poster, which highlights data from the company’s open label, Phase IV clinical study in which 91 healthy, adult volunteers aged 20 to 40 received 10 mg/mL of VBI’s third-generation Hepatitis B (HBV) vaccine, Sci-B-Vac®. Immunization with Sci-B-Vac® resulted in rapid seroprotection after two Sci-B-Vac® vaccinations, and high anti-hepatitis B surface antigen (HBsAg) geometric mean titers (GMTs). Moreover, the majority of the participants with high GMTs also possessed antibody responses against the HBsAg Pre-S1 and Pre-S2 domains.Preliminary data highlights the utility of the inclusion of pre-S1 and pre-S2 antigens and suggests a significant contribution of the Pre-S domains to the rapid kinetics and protective titer of antibodies against HBsAg, which may correlate with improved immunogenicity.

Posters of Distinction are classified as being in the top 10% of scored poster abstracts and will receive special recognition in the Poster Hall.

Poster Presentation Details
  • Poster Number: 1865
  • Event: American Association for the Study of Liver Diseases, The Liver Meeting® 2017
  • Date: Monday, October 23, 2017
  • Time: 8:00 AM to 5:30 PM ET
  • Event Website: http://2017-aasld.org
About Sci-B-Vac®

Sci-B-Vac® is a licensed third-generation hepatitis B vaccine that has demonstrated safety and efficacy in more than 300,000 patients. Sci-B-Vac is currently approved for use in Israel and in 14 other countries. In contrast to second-generation hepatitis B vaccines, which contain only one surface antigen (the S antigen), Sci-B-Vac contains the S antigen and the pre-S1 and pre-S2 surface antigens. The composition of Sci-B-Vac may prove more immunogenic in subjects that currently do not respond optimally to second-generation vaccines.

To learn more about Sci-B-Vac®, visit: https://www.vbivaccines.com/sci-b-vac/