Our Clinical Trials

From Science to the Clinic – and Beyond

Our team works hard to drive our innovative pipeline programs into and through clinical development to assess the safety, tolerability, and immunogenicity of each candidate.

We are grateful for the many volunteers and medical experts who participate in our studies, without whom we could not reach our goal of better health for all.


Hepatitis B

Prophylactic Vaccine Candidate: 3-Antigen HBV Vaccine (Sci-B-Vac®)

Study PROTECT

Phase 3: A double-blind randomized controlled trial designed to establish the non-inferiority of Sci-B-Vac® compared to Engerix-B® in adults ≥ 18 years old and the superiority of Sci-B-Vac® compared to Engerix-B® in ≥ 45 years old.

Status: Completed

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Study CONSTANT

Phase 3: A double-blind randomized controlled trial to assess the lot-to-lot consistency of Sci-B-Vac® in adults

Status: Completed

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Immunotherapeutic Candidate: VBI-2601

Phase 1b/2a: Ongoing study evaluating the safety, tolerability, and antiviral activity of VBI-2601 (BRII-179) as a component of a functional cure for chronic HBV infection, developed in partnership with Brii Biosciences.

Status: Active, Not Recruiting

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Glioblastoma

Immunotherapeutic Candidate : VBI-1901

Phase 1/2a: Ongoing study evaluating the safety, tolerability, and optimal dose of VBI-1901 in subjects with recurrent GBM.

Status: Active, Not Recruiting

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Coronaviruses

Prophylactic Vaccine Candidate : VBI-2902

Adaptive Phase 1/2: Ongoing study evaluating the safety, tolerability, and immunogenicity of VBI-2902a in healthy adults 18 years of age and above

Status: Active, Recruiting

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Cytomegalovirus

Prophylactic Vaccine Candidate : VBI-1501

Phase 1: Study to compare the safety and effectiveness of four different doses of VBI’s CMV vaccine candidate in healthy adults.

Status: Completed

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