- Rapid, potent, and durable immunity demonstrated with vaccine candidate (VBI-1501A).
- Pilot scale (10L) production of VBI-1501A expected to meet Phase I trial release criteria.
VBI presented new data last week that demonstrates continued support for the development of the company’s prophylactic CMV vaccine candidate (VBI-1501A).
The oral presentation, A Prophylactic Human Cytomegalovirus (HCMV) Vaccine Designed to Prevent Congenital Infection Using Enveloped Virus-Like Particles (eVLPs), was delivered by Dr. David E. Anderson, VBI’s Senior Vice President of Research, at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) held in Washington, D.C. The presentation, previously under embargo, is now available for download here: https://www.vbivaccines.com/wire/icaac-presentation/
“The limited potency and durability of immunity induced with past CMV vaccine candidates have hindered their potential efficacy. VBI’s preclinical animal data demonstrates that VBI-1501A has substantially improved potency and durability, at levels now exceeding a benchmark for naturally acquired immunity. Technology transfer to the contract manufacturer of our toxicology and clinical batches of VBI-1501A is currently on track to support an IND submission and phase I start in Q4 2015,” commented Dr. Anderson.
Now in its 54th year, ICAAC is a leading conference on antimicrobial agents and infectious diseases and showcases the latest-breaking science and lectures from top researchers around the world. ICAAC brings together the field’s foremost leaders to discuss the state of infection control and prevention on a global scale.
VBI Vaccines Inc. (“VBI”) is a biopharmaceutical company developing novel technologies that seek to expand vaccine protection in large underserved markets. VBI’s eVLP vaccine platform allows for the design of enveloped (“e”) virus-like particle (“VLP”) vaccines that closely mimic the target virus. VBI’s lead eVLP asset is a prophylactic Cytomegalovirus (“CMV”) vaccine; VBI has initiated work for GMP manufacturing of its CMV candidate for use in formal preclinical and Phase I trials. VBI’s LPV platform is a thermostable technology that enables the development of vaccines and biologics that can withstand storage or shipment at constantly fluctuating temperatures. VBI has completed proof of concept thermostability studies on a number of vaccine and biologic targets. VBI is headquartered in Cambridge, MA with research facilities in Ottawa, Canada.
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