Research Scientist/Scientific Engineer, Downstream Process Development

A new opportunity has opened up within our Research and Development operation for a Research Scientist/Scientific Engineer in our Ottawa, Ontario Canada location. Reporting to the Process and Analytical Development Lead you will be involved in downstream process development activities for our enveloped Virus Like Particle (eVLP) platforms. The Downstream Process Development team is responsible for the development and implementation of downstream processing methodologies and analytical procedures that can be easily transferred to a cGMP Manufacturing site.

Key Responsibilities

  • Develop & support scalable purification process by evaluating novel and advanced technologies for our eVLP platforms
  • Lead efforts to evaluate and optimize different membranes, resins and filters as part of the purification development activities
  • Serve as subject matter expert for the design of process development studies, data analysis and interpretation of data
  • Support scale-up of the manufacturing processes and technology transfer to VBI’s partners and CMOs
  • Employ quality by design principals to perform process characterization studies such as impurity clearance, process limit evaluations, and identifying operational design space
  • Support the training of lab staff on downstream purification equipment
  • Prepare and review study protocols, reports, test-methods, SOP’s, etc.
  • Perform duties in compliance with VBI’s employment, health & safety, and labour policies, procedures and regulations
  • Effectively collaborate with a fully integrated team to facilitate the success of projects

Qualifications and Experience

  • Masters or PhD in Biotechnology, Biochemical Engineering or in other related Science field (Virology, Biology, Biochemistry, Protein Chemistry, Pharmaceutical Chemistry)
  • 3-5 years of experience in downstream process development, chromatography and filtration methods (chromatography, tangential flow, ultrafiltration)
  • Experience in viral clearance techniques, process scaling and technology transfer
  • Experience with mammalian cell culture in suspension bioreactors is considered an asset
  • Able to manage competing priorities effectively and adapt to changing priorities
  • Strong analytical, organizational, time management and problem-solving skills
  • Excellent communication skills with the proven ability to work as a member of a multidisciplinary team
  • Excellent computer skills including Microsoft excel, PowerPoint, Word and Prism

    How to Apply

    If this describes you please introduce yourself by submitting your resume and cover letter outlining your qualifications and interest in joining VBI’s team to

    We thank all applicants for their interest, however, only those selected for an interview will be contacted.

    VBI is an Equal Opportunity Employer who firmly believes our diversity fosters innovation. Accommodations are available upon request for candidates with disabilities participating in all aspects of the selection process.

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